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Association Between Platelet Count and Congestive Heart Failure in Chronic Kidney Disease Participants: Results From
Background:
The primary objective of this study was to examine the association between platelet count (PLT) and congestive heart failure (CHF) in patients with chronic kidney disease (CKD).
Methods:
Data from the National Health and Nutrition Examination Survey (NHANES, 2007-2018) were used to investigate the association between PLT and CHF in patients with CKD. Demographics, laboratory, and comorbidities data were analyzed. Multivariable logistic regression, stratified analysis, curve fitting, and subgroup analyses were performed to assess the association between PLT and CHF.
Results:
A total of 2,540 participants were included, comprising 230 with CHF and 2,310 without CHF. In multivariable logistic regression analysis, after adjusting for various confounders across three models, PLT was inversely associated with CHF. Each 10×10³/µL increase in PLT was associated with lower odds of CHF in the crude model (OR 0.918, 95% CI: 0.897-0.940). The PLT-CHF relationship followed a linear trend (P for non-linearity = 0.567). Subgroup analysis revealed a significant interaction between female sex and CHF risk (P for interaction < 0.05).
Conclusion:
PLT was independently associated with CHF in patients with CKD. Each 10×10³/µL increment in PLT corresponded to lower odds of CHF in Model III.