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NAD+ augmentation in brain aging: hype, hope, or emerging reality?
He-Ling Wang1, Jianying Zhang2, Evandro Fei Fang3
1Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway.
Trends in Endocrinology and Metabolism: TEM
|September 22, 2026
Abstract:
Restoring NAD+ to physiological levels shows promise for countering brain aging and neurodegeneration, backed by preclinical and growing clinical evidence. Key challenges remain: measurement validity, brain delivery, optimal dosing, and trial design. This forum examines current evidence, addresses ongoing controversies, and outlines priorities for future research and translation.