Reply to 'Methodological concerns and interpretative limitations of assessing subjective effects of ketamine'

This response addresses methodological concerns raised regarding our meta-analysis of subjective effects and therapeutic outcomes following ketamine and psilocybin treatment. We discuss the potential influence of psychotherapy and differences in subjective-effect questionnaires across studies, acknowledging these as important limitations. We argue that these factors may partly explain observed treatment differences and highlight the need for future studies using standardized, multidimensional measures of subjective experience.