Neural regulatory networks: challenges and opportunities in the treatment of psoriasis

Psoriasis is a chronic systemic inflammatory skin disease characterized by complex pathogenic mechanisms involving various cellular interactions. The nervous system significantly influences the development and exacerbation of psoriatic lesions, particularly in innervated regions. Despite the recognized importance of these interactions, a comprehensive understanding of the underlying mechanisms between different cell types and the nervous system in psoriasis is still lacking. This review systematically explores the intricate regulatory interactions between multiple cellular components and the nervous system in psoriasis. We aim to identify potential therapeutic targets and propose innovative strategies to improve clinical outcomes of patients with psoriasis.