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Rationale for a live-attenuated vaccine for cryptosporidiosis
A Clinton White1, Sara M Dann1, Alejandro Castellanos-Gonzalez1
1Infectious Disease Division, Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555-0435 USA.
The Journal of Infectious Diseases
|September 23, 2026
Abstract:
Natural Cryptosporidium infection causes development of protective immunity. Live-attenuated vaccines stimulate both adaptive and "trained" innate immune responses. With advances in parasite genetics, target identification, and in vitro cultivation, we now propose development of a live-attenuated vaccine for cryptosporidiosis.