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Updated: Sep 24, 2026

Molecular Profiling of the Invasive Tumor Microenvironment in a 3-Dimensional Model of Colorectal Cancer Cells and Ex vivo Fibroblasts
Published on: April 29, 2014
Identification of anoikis-related and cell matrix adhesion genes in the progression of colon adenocarcinoma using
Ting Zheng1, Xingxing Li1, Li Zhou1
1Department of Medical Oncology, The First People's Hospital of Linping District, Hangzhou, Zhejiang Province, China.
Abstract:
To develop an innovative prognostic model for colon adenocarcinoma (COAD), we integated anoikis- and cell matrix adhesion (CMA related mechanisms using TCGA and GEO datasets. Six genes (BST2, NAT1, OFCC1, HOTAIR, TRIP6, ADAMTS13) were identified, risk model stratified patients into high- and low risk groups with distinct survival (p=0.025), validated in GSE17536. A nomogram showed good predictive accuracy. Functional enrichment highlighted tumor-, anoikis-, and CMA-related pathways, immune infiltration correlated with prognostic signature and risk score. High-risk patients were more sensitive to afatinib, osimertinib, and navitoclax; low-risk patients to paclitaxel, docetaxel, and gemcitabine. These genes may serve as prognostic biomarkers and guide tailored COAD therapy.
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