Role of the miR-1298/Bone Morphogenetic Protein 7 Axis in Colorectal Cancer

The incidence of colorectal cancer (CRC) has been on the rise in recent years. We explored the clinical significance and molecular mechanisms of miR-1298 in CRC. A total of 85 patients with CRC were enrolled. All gene levels were evaluated by RT-qPCR. In CRC cells, the levels of miR-1298 and bone morphogenetic protein 7 (BMP7) were regulated using cell transfection. The target of miR-1298 was predicted using bioinformatics analysis and was identified by the dual-luciferase reporter system. CRC cell function was assessed utilizing the CCK-8 assay, the Transwell assay, and flow cytometry. The correlation between miR-1298 and BMP7 in CRC tissues was analyzed utilizing Pearson's correlation. miR-1298 was substantially downregulated in CRC and was associated with malignant clinicopathological features. In CRC cells, miR-1298 suppressed proliferation, migration, and invasion, and elevated apoptosis. BMP7 was a downstream target of miR-1298 and was negatively correlated with miR-1298. Overexpression of BMP7 partially reversed the suppressive effect of miR-1298 on proliferation, migration, and invasion in CRC cells, as well as its promotion of apoptosis. miR-1298 was related to invasion and migration and may suppress the progression of CRC. BMP7 may be a potential functional mediator of miR-1298 in CRC.