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Published on: June 20, 2014
Visible-light-driven carbamoyl radical addition to 3-methylene isoindolinones
Nathan Martin1, Roberto Doville1, Lou-Anne Beghin1
1Univ. Lille, CNRS, Centrale Lille, ENSCL, Univ. Artois, UMR 8181, Unité de Catalyse et Chimie du Solide, F-59000 Lille, France. till.bousquet@univ-lille.fr.
Abstract:
An efficient method for the synthesis of 3-substituted isoindolinones is described. The addition of a carbamoyl group from carbamoyl-dihydropyridine onto 3-methylene isoindolinones provides amide functionalization under visible light irradiation, in the presence of an organic photocatalyst. This protocol offers mild reaction conditions, a broad substrate scope, and an excellent functional group tolerance, affording a range of structurally diverse 3-amido isoindolinones in good to excellent yields.
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