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Updated: Sep 24, 2026

Meiotic Spindle Assessment in Mouse Oocytes by siRNA-mediated Silencing
Published on: October 11, 2015
Subtlety is underrated: Physiological UPR activation in meiosis
David Pincus1,2,3, Vladimir Denic4
1Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL, USA.
Abstract:
In this issue, Bartolutti et al. (https://doi.org/10.1083/jcb.202509100) identify a physiological function for the unfolded protein response (UPR). The UPR has long been viewed as a coping mechanism for protein misfolding in the endoplasmic reticulum (ER). The authors here show that budding yeast naturally use this response to reorganize their ER during meiosis and sporulation, suggesting an ancient origin for the UPR as an adaptive developmental program.
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