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Interpreting prediagnostic corticosteroid use in Acanthamoeba keratitis: corticosteroid type and inflammatory
Suguru Nakagawa1, Hiroko Takano2, Machiko Shimmura-Tomita2
1Department of Ophthalmology, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma-cho, Omiya-ku, Saitama, Saitama, 330-8503, Japan. snakagawa-tky@umin.ac.jp.
Key Messages:
WHAT IS KNOWN : Prediagnostic corticosteroid use in Acanthamoeba keratitis has often been associated with delayed diagnosis and poor outcomes, although its independent prognostic significance remains uncertain.
What Is New:
Prediagnostic corticosteroid exposure may warrant characterization beyond a binary variable; corticosteroid agent/type and relative potency remain hypothesis-generating considerations. Keratic precipitates are nonspecific and may represent one component of the inflammatory phenotype; their prognostic significance in Acanthamoeba keratitis remains exploratory.
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