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Updated: Sep 25, 2026
Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss
Published on: January 25, 2016
[Construction and validation of a prognosis prediction model for patients with high-frequency predominant sudden
1Department of Audiology and Vestibular Medicine, Senior Department of Otolaryngology Head and Neck Surgery, Sixth Medical Center of Chinese PLA General Hospital, State Key Laboratory of Hearing and Balance Science, National Clinical Research Center for Otolaryngologic Diseases, Beijing 100853, China.
Abstract:
Objective: To investigate the prognostic factors of high-frequency predominant sudden sensorineural hearing loss with concomitant middle- and low-frequency involvement, and develop a prognostic prediction model. Methods: The clinical data of patients with high-frequency predominant sudden sensorineural hearing loss with concomitant middle-and low-frequency involvement at the Chinese PLA General Hospital between January 2009 and April 2025 were retrospectively analyzed. Patients were divided into effective and ineffective groups based on their prognosis. A prognostic prediction model was established using multivariable logistic regression analysis, and a nomogram was constructed. The performance of the model was evaluated by receiver operating characteristic (ROC) curve, Hosmer-Lemeshow goodness-of-fit test, and decision curve analysis (DCA). Results: A total of 170 patients aged 48 (38, 56) years were included, comprising 96 males (56.5%) and 74 females (43.5%). The overall treatment effective rate was 27.6% (47/170). Multivariable logistic regression analysis showed that prolonged time from onset to presentation (OR=1.17, 95%CI: 1.10-1.26, P<0.001), increased age (OR=1.09, 95%CI: 1.05-1.13, P<0.001), and decreased high-density lipoprotein cholesterol (HDL-C) (OR=4.00, 95%CI: 1.21-13.20, P=0.023) were independent risk factors for poor prognosis in patients with high-frequency predominant sudden sensorineural hearing loss with concomitant middle- and low-frequency involvement. The area under the ROC curve (AUC) of the prediction model was 0.88 (95%CI: 0.82-0.93). The calibration curve demonstrated good fit, with the Hosmer-Lemeshow goodness-of-fit test yielding χ2=7.157 and P=0.520. DCA showed that the model yielded a positive net benefit when the risk threshold probability ranged from 0.04 to 0.99. Conclusions: Time from onset to presentation, age, and HDL-C are prognostic factors in patients with high-frequency predominant sudden sensorineural hearing loss with concomitant middle- and low-frequency involvement. The nomogram developed based on these variables demonstrates good predictive ability for treatment prognosis in these patients.
