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Updated: Sep 25, 2026

Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
Published on: August 14, 2019
Functionalization of Flavonoids with Lipases
Elisa Gutierrez-Navarro1,2,3,4, José Daniel Padilla-de la Rosa2, Georgina Sandoval3
1Industrial Microbiology Laboratory, University Center of Exact Sciences and Engineering of University of Guadalajara, Guadalajara, Jalisco, Mexico.
Abstract:
Flavonoids, valued for their health benefits, face challenges due to low solubility. Enzymatic acylation offers promise in enhancing properties, with the use of lipase B sourced from Candida antarctica (N435). This study has the aim to improve naringin solubility via esterification using as acyl donors short- and medium-chain fatty acids (vinyl acetate, propionate, and laurate) catalyzed by N435. Lipases play a crucial role as catalysts, facilitating the acylation process. Our study encompasses executing acylation and characterizing products. This process significantly enhances aqueous and organic solvent solubility of naringin esters. Additionally, acylating flavonoids with these fatty acids has the potential to broaden their range of applications in understanding and modulating gut health.
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