A single-step phosphorylation of 5-fluoro-2'-deoxyuridine to 5-fluoro-2'-deoxyuridine 5'-phosphate

Human thymidylate synthase is in the closed conformation when complexed with dUMP and raltitrexed, an antifolate drug.

Biochemistry·2001

Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors.

The Journal of biological chemistry·2001

Cation binding and thermostability of FTHFS monovalent cation binding sites and thermostability of N10-formyltetrahydrofolate synthetase from Moorella thermoacetica.

Biochemistry·2000

Catalytic cysteine of thymidylate synthase is activated upon substrate binding.

Biochemistry·2000

The crystal structure of N(10)-formyltetrahydrofolate synthetase from Moorella thermoacetica.

Biochemistry·2000

Kinetic studies on drug-resistant variants of Escherichia coli thymidylate synthase: functional effects of amino acid substitutions at residue 4.

Archives of biochemistry and biophysics·1999

Structural and Mechanistic Studies of ADEPs Yield Potent Antibacterials and a Drug Formulation Strategy for Tuberculosis.

Journal of medicinal chemistry·2026

A 177Lu-Labeled Circular Bivalent Aptamer for PTK7-Targeting Radionuclide Therapy in Ovarian Cancer and Orthotopic Hepatoblastoma.

Journal of medicinal chemistry·2026

From Fragment Hit to Clinical Candidate: Discovery of Dual H1R/H4R Ligands with Superior Efficacy in Allergic Conjunctivitis.

Journal of medicinal chemistry·2026

Potent Anticancer Tethered Organorhodium(III) Complexes Target the Mitochondria.

Journal of medicinal chemistry·2026

Discovery of a Covalent NLRP3 LRR-Domain Probe: Reversing Renal Fibrosis via Immunometabolic Reprogramming in Organoid and Murine Models.

Journal of medicinal chemistry·2026

Lead Optimization of Multimutant KRAS Switch-II Pocket Macrocyclic Inhibitors via Isosteric Replacement to Improve ADME and Oral Exposure.

Journal of medicinal chemistry·2026

Treatment-resistant hypertension in the primary care setting.

Journal of osteopathic medicine·2026

Cognition endpoints for Parkinson's disease: A roadmap for developing patient-focused assessment tools to accelerate drug development.

Journal of Parkinson's disease·2026

Dose-stratified lipid-lowering efficacy and safety of oral PCSK9 inhibitors: a systematic review and meta-analysis.

Journal of cardiovascular medicine (Hagerstown, Md.)·2026

Pharmacological stratification of fall-risk-increasing drugs for prevention of fall-related injuries in older adults: a population-based cohort study.

Age and ageing·2026

Obstetric pharmacoeconomics.

Expert review of pharmacoeconomics & outcomes research·2026

Depot medroxyprogesterone acetate and the risk for developing an intracranial meningioma.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics·2026

Related Experiment Videos

A single-step phosphorylation of 5-fluoro-2'-deoxyuridine to 5-fluoro-2'-deoxyuridine 5'-phosphate

Related Concept Videos

Human thymidylate synthase is in the closed conformation when complexed with dUMP and raltitrexed, an antifolate drug.

Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors.

Cation binding and thermostability of FTHFS monovalent cation binding sites and thermostability of N10-formyltetrahydrofolate synthetase from Moorella thermoacetica.

Catalytic cysteine of thymidylate synthase is activated upon substrate binding.

The crystal structure of N(10)-formyltetrahydrofolate synthetase from Moorella thermoacetica.

Kinetic studies on drug-resistant variants of Escherichia coli thymidylate synthase: functional effects of amino acid substitutions at residue 4.

Structural and Mechanistic Studies of ADEPs Yield Potent Antibacterials and a Drug Formulation Strategy for Tuberculosis.

A 177Lu-Labeled Circular Bivalent Aptamer for PTK7-Targeting Radionuclide Therapy in Ovarian Cancer and Orthotopic Hepatoblastoma.

From Fragment Hit to Clinical Candidate: Discovery of Dual H1R/H4R Ligands with Superior Efficacy in Allergic Conjunctivitis.

Potent Anticancer Tethered Organorhodium(III) Complexes Target the Mitochondria.

Discovery of a Covalent NLRP3 LRR-Domain Probe: Reversing Renal Fibrosis via Immunometabolic Reprogramming in Organoid and Murine Models.

Lead Optimization of Multimutant KRAS Switch-II Pocket Macrocyclic Inhibitors via Isosteric Replacement to Improve ADME and Oral Exposure.

Treatment-resistant hypertension in the primary care setting.

Cognition endpoints for Parkinson's disease: A roadmap for developing patient-focused assessment tools to accelerate drug development.

Dose-stratified lipid-lowering efficacy and safety of oral PCSK9 inhibitors: a systematic review and meta-analysis.

Pharmacological stratification of fall-risk-increasing drugs for prevention of fall-related injuries in older adults: a population-based cohort study.

Obstetric pharmacoeconomics.

Depot medroxyprogesterone acetate and the risk for developing an intracranial meningioma.

Related Experiment Videos

A single-step phosphorylation of 5-fluoro-2'-deoxyuridine to 5-fluoro-2'-deoxyuridine 5'-phosphate

Related Concept Videos

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