Related Experiment Video
Updated: Sep 25, 2026
Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye
Published on: June 20, 2015
Investigating intraocular pressure fluctuations using corneal visualization Scheimpflug technology tonometry (CST)
Xiaoqin Chen1,2,3, Hongsu Wang4, Xingyi Guo3
1Tianjin Eye Hospital, Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin, China.
Background:
To investigate the effects of different resting intervals on successive intraocular pressure (IOP) and biomechanically corrected IOP (bIOP) measurements from corneal visualization Scheimpflug technology tonometry (CST).
Methods:
This was a prospective repeated-measures observational study in young healthy myopes. Three successive IOP and bIOP measurements were acquired using the CST in both eyes of each participant, using four intervals between three successive measurements in the following order, 5 min (T5), 2 min (T2), 30 s (T30), and immediately after the other (Ti). T5-1 was the baseline measurement followed by T5-2 5 minlater, and T5-3 after another 5-min interval. A similar approach was applied to other intervals. A 5-min resting period was provided between successive sets of triplicate measurements. IOP and bIOP results were compared with four intervals and three measurements as the main effects.
Results:
A total of 88 myopic participants were recruited. Their mean age was 21.5 ± 2.5 years (from 19 to 31 years). There were 68 right eyes and 20 left eyes, with a spherical equivalent of -4.49 ± 2.39 D (from -9.88 to -0.50 D). A generalized linear mixed model showed that the order of interval did not show significant effect on IOP (p = 0.404), nor the measurement interval (p = 0.074). For bIOP, interval did not show significant effect (p = 0.325) whereas difference in measurement interval, and the effect of successive measurement approached statistical significance (p = 0.054). There was a decreasing trend of bIOP when measurement intervals were 2 min (Friedman test, p < 0.001) and 30 s (Friedman test, p = 0.035). The difference was less than 1 mmHg.
Conclusion:
Both IOP and bIOP obtained from CST were stable across successive measurement. Although bIOP decreased slightly with 2-min and 30-s, the reduction was small and not clinically significant.
