Machine learning-based risk prediction models for type 2 diabetes in primary care: a scoping review

Type 2 diabetes mellitus (T2DM) is a major global public health challenge, with many individuals remaining undiagnosed until complications develop. Machine learning (ML)-based risk prediction models have the potential to support early identification of individuals at increased risk using primary care data. However, the characteristics and applicability of these models within primary care settings have not been comprehensively mapped.

To systematically map the available evidence on machine learning (ML)-based models for risk prediction, early detection, and case-finding of type 2 diabetes in primary care, and to summarize their characteristics, including predictors, modeling approaches, validation strategies, and model performance.

A scoping review was conducted following the Joanna Briggs Institute methodology and reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR). PubMed/MEDLINE, Scopus, and Ovid MEDLINE were searched for English-language studies published between January 2011 and December 2025. Primary research describing ML-based risk prediction models developed, validated, evaluated, or intended for implementation in primary care was eligible. Data were extracted using a structured charting form and synthesized descriptively.

The search identified 186 records, of which four studies met the inclusion criteria. The included studies were conducted in Sweden, Canada, Saudi Arabia, and Hong Kong between 2024 and 2025. Three studies focused on model development and internal validation, while one externally validated previously developed non-laboratory prediction models. A range of ML approaches was identified, including stochastic gradient boosting, federated learning, multilayer perceptron, random forest, support vector classification, naïve Bayes, and decision tree algorithms, with logistic regression commonly used as a comparator. Models primarily utilized routinely collected demographic, anthropometric, lifestyle, and electronic health record-derived variables. Most studies reported moderate-to-good predictive performance; however, evidence regarding external validation, calibration, and prospective implementation within routine primary care remained limited.

Evidence on ML-based risk prediction models for T2DM applicable to primary care remains limited despite growing interest in AI for diabetes prediction. Existing models demonstrate promising predictive performance using routinely available clinical information, but greater emphasis is needed on external validation, calibration, prospective implementation, and evaluation across diverse primary care populations before widespread clinical adoption.

Open Science Framework https://osf.io/mbfrz.