56-year trends and disparities in systemic sclerosis mortality in the United States, 1968-2023: a retrospective...

To describe long-term US trends in SSc mortality and disparities by sex, race, region and age.

This was a retrospective population-based mortality study using CDC WONDER data from 1968 to 2023. We identified deaths with SSc as the underlying cause of death (UCD) and calculated annual age-adjusted mortality rates (AAMRs) per 1 000 000 population standardized to the 2000 US standard population. Joinpoint regression was used to estimate annual percent change (APC) and average annual percent change (AAPC). Sensitivity analyses used multiple cause of death (MCOD) data (1999-2023).

Among 55 567 SSc-UCD deaths, the annual number increased from 466 in 1968 to 1005 in 2023. The national AAMR increased from 2.66 (1968) to 4.87 (2001) and decreased to 2.37 (2023). Joinpoints occurred in 1987, 2001 and 2013; the steepest decline followed 2013 (APC -4.07%), with an overall AAPC of -0.44%. Female AAMR exceeded male AAMR throughout (female:male ratio from 2.0 to 3.6) and mortality declined more in males than females (AAPC -1.08% vs - 0.02%). Black/African American individuals had higher AAMRs than White individuals but a larger net decrease (AAPC -0.80% vs - 0.33%). Mortality increasingly concentrated in adults ≥65 years of age, who showed a net increase over 1968-2023 (AAPC 1.07%). Across US census regions, mortality peaked in the early 2000s and declined thereafter, with broadly similar post-peak trajectories. In MCOD sensitivity analyses, AAMRs declined overall from 7.06 to 3.79 during 1999-2023 (AAPC -2.45%), although the most recent MCOD segment did not show a statistically significant decline.

Despite the observed long-term decline in SSc-UCD mortality, deaths remained unevenly distributed by sex, race and age. These findings support risk-stratified follow-up and closer monitoring of older adults, women, Black/African American patients and other patients at elevated risk.