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Synthetic Cell-Based Approaches to Dissect Autonomous Cellular Oscillators: Recent Applications on the Cell Cycle

Yeonghoon Kim1, Franco Tavella1, Qiong Yang2,3

  • 1Department of Biophysics, University of Michigan, Ann Arbor, MI, USA.

Advances in Experimental Medicine and Biology
|September 24, 2026
PubMed

Keywords:
Bistable switchCell-free extract systemsCyclin B-Cdk1 networkEnergy flowHigh-throughput single-cell perturbation and analysisMitotic wavesPP2A-Greatwall pathwayParameter space mappingPositive and negative feedback loopsRelaxation oscillatorRobustness and tunabilitySaddle-node bifurcationSpatiotemporal synchronizationTemperature scalingWater-in-oil microemulsions

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