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Updated: Sep 26, 2026

Modeling the Functional Network for Spatial Navigation in the Human Brain
Published on: October 13, 2023
Toward a Multi-View Brain Network Foundation Model: Cross-View Consistency Learning across Arbitrary Atlases
Abstract:
Brain network analysis provides an interpretable framework for characterizing brain organization and has been widely used for neurological disorder identification. Recent advances in self-supervised learning have motivated the development of brain network foundation models. However, existing approaches are often limited by atlas dependency, insufficient exploitation of multiple network views, and weak incorporation of anatomical priors. In this work, we propose MV-BrainFM, a multi-view brain network foundation model designed to learn generalizable and scalable representations from brain networks constructed with arbitrary atlases. MV-BrainFM explicitly in-corporates anatomical distance information into Transformer based modeling to guide inter-regional interactions, and introduces an unsupervised cross-view consistency learning strategy to align representations from multiple atlases of the same subject in a shared latent space. By jointly enforcing within view robustness and cross-view alignment during pretraining, the model effectively captures complementary information across heterogeneous network views while remaining atlas-aware. In addition, MV-BrainFM adopts a unified multi-view pretraining paradigm that enables simultaneous learning from multiple datasets and atlases, significantly improving computational efficiency compared to conventional sequential training strategies. The proposed framework also demonstrates strong scalability, consistently benefiting from increasing data diversity while maintaining stable performance across unseen atlas configurations. Extensive experiments on more than 20,000 subjects from 17 fMRI datasets show that MV-BrainFM consistently outperforms 14 existing brain network foundation models and task-specific baselines under both single-atlas and multi-atlas settings. Furthermore, the learned representations exhibit strong anatomical and clinical interpretability, highlighting meaningful brain regions and cross-view consistent patterns associated with neurological conditions. These results suggest that MV-BrainFM provides an effective, efficient, and scalable foundation model for brain network analysis. The source code is available at https://github.com/AngusMonroe/MV-BrainFM.
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