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Proposed Strategies to Increase the Likelihood of Achieving Remission in CRSwNP by EUFOREA
P W Hellings1, S E Lee2, E De Corso3
1Laboratory of Allergy and Clinical Immunology Research Unit, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium; Upper Airways Research Laboratory, Department of Head and Skin, Ghent University, Belgium; Department of Otorhinolaryngology, Head and Neck Surgery, University Hospitals Leuven, Leuven, Belgium.
Abstract:
Remission in CRSwNP is considered the new aim of care given the reality of being able to achieve long-term disease control in patients with previously severe uncontrolled sinus disease following the combination of complete sinus surgery and long-term therapy with biologics. The state of remission helps patients to lead a normal life without negative impact on their well-being, saves costs for health care systems, and holds promise for future cure. The likelihood of severe uncontrolled CRSwNP patients to achieve remission after more than 18 months of therapy with biologics has been reported to be around 40% in real life registries. Based on recent literature in CRSwNP and international consensus amongst EUFOREA expert panel members, the health care community may consider several strategies that are likely to further increase the number of patients with severe CRSwNP achieving remission. In this paper we provide an overview of four different strategic categories that may alone or in combination contribute to increasing the likelihood of severe uncontrolled CRSwNP patients achieving remission. These are divided, albeit arbitrarily, into the following categories: the health care system, the medical community, the therapeutic approach, and the patient community.
