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Impact of a Short-term Yoga Lifestyle Programme on Circulating Serum Klotho Levels in Patients with Type 2 Diabetes:
Atmakur Snigdha1, Vijaya Majumdar1, Kalpana S Ramegowda2
1Division of Yoga and Life Science, Swami Vivekananda Yoga Anusandhana Samsthana (SVYASA), Bengaluru, Karnataka, India.
Introduction:
Klotho, an anti-ageing protein involved in metabolic regulation, is downregulated in type 2 diabetes mellitus (T2DM). Prior studies suggest that enhancing Klotho expression may help manage diabetes and its complications. Yoga, with its systemic effects, may offer a promising non-pharmacological approach. The present study aimed to evaluate the effect of a 15-day structured yoga lifestyle (SYL) programme on serum Klotho levels and glycaemic parameters in individuals with T2DM.
Methods:
This single-arm, open-label exploratory study was conducted on 74 adults (30-65 years) with T2DM. The SYL programme included asanas, pranayama, meditation, kriyas, a satvik diet, and spiritual sessions. Pre- and post-assessments included serum Klotho, fasting blood glucose (FBG), postprandial blood glucose (PPBG), and blood pressure (BP). The Wilcoxon signed-rank test was used.
Results:
Serum Klotho levels increased significantly by 14.65% (P < 0.001). FBG and PPBG were reduced by 5.97% and 3.68%, respectively (P < 0.001). Systolic BP was reduced modestly (P = 0.025); diastolic BP showed no change. Subgroup analysis showed greater Klotho increase in those aged > 55 years, females, non-hypertensives, and those with a longer duration of diabetes (P < 0.05).
Conclusion:
The findings support SYL as a potential adjunct therapy. Longer controlled trials are needed to further establish these results.
