Related Experiment Video
Updated: Sep 26, 2026

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies
Published on: April 11, 2016
From free text to structured genomics: future-proofing cancer registries for precision oncology
1Department of Medicine, Data Integration Center, Giessen University Hospital, Giessen, Germany.
Abstract:
Molecular pathology has become central to precision oncology, but German cancer registry data structures were designed for simpler molecular findings. This study argues that registries need a minimal, structured, and interoperable representation of molecular variants that remains compatible with data minimization and existing reporting infrastructures. Using the German oncology core dataset (nationally standardized oncological core dataset for cancer reporting-einheitlicher onkologischer Basisdatensatz [oBDS]) as an example, we outline conceptual principles for a backward-compatible molecular data structure and propose a future agenda for consensus-building, pilot implementation, and impact evaluation.
Related Concept Videos
Next-generation Sequencing
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features.
Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Cancer-Critical Genes II: Tumor Suppressor Genes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes II: Tumor Suppressor Genes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Genomics
Sanger Sequencing

