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Published on: May 2, 2017
Inflammation and delirium in critically Ill patients: a review
Liang Li1, Xiaoli Wang2, Jialin Liu1,3
1Department of Geriatrics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Abstract:
The high prevalence and adverse impact of delirium in critically ill patients necessitate a deeper understanding of its mechanisms. This review explores the pivotal interplay between systemic inflammation and delirium, examining how insults like age, pain and surgery orchestrate neuroinflammation and delirium through microglial activation and blood-brain barrier disruption. Our synthesis identifies a spectrum of inflammatory and neuronal injury biomarkers with prognostic value and evaluates the burgeoning field of anti-inflammatory pharmacotherapy. We conclude that bridging this mechanistic knowledge to clinical practice via biomarker-driven trials is essential for developing effective interventions against delirium.
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