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Brazil HARMONY: Improved Satisfaction With Facial Appearance and Psychosocial and Social Well-Being Following
Background:
Multimodal facial aesthetic treatment has potential benefits that extend beyond facial enhancements.
Objectives:
The aim of this study was to assess satisfaction with improvement in facial appearance and quantify the psychological, social, and emotional impact of comprehensive, multimodal, full-face aesthetic injectable treatment.
Methods:
In this prospective, open-label, multisite study, participants (n = 64) sequentially received a combination of a hybrid injectable containing hyaluronic acid (HA) plus calcium hydroxyapatite, HA injectables, and onabotulinumtoxinA over 5 months. The primary efficacy endpoint was change in FACE-Q Satisfaction with Facial Appearance Overall scale score. Secondary endpoints included the following assessments: FACE-Q Aging Appraisal, Psychological Function, Social Function, and Satisfaction with Skin; Global Aesthetic Improvement Scale (GAIS); Periorbital Aesthetic Appearance Questionnaire (PAAQ); and participant self-perception of facial age. Outcomes were measured as change in score from baseline to final visit.
Results:
Participants demonstrated significant improvement on the FACE-Q Satisfaction with Facial Appearance Overall scale (mean score increase = 46.6; P < .0001). In secondary efficacy analyses, significant improvement was observed on FACE-Q Psychological Function, Social Function, Aging Appraisal, and Satisfaction with Skin scales (P < .0001) and PAAQ (P < .0001). All investigators and participants noted improvement in facial appearance on the GAIS. A majority (85.5%) of participants reported improvement in age-related facial appearance. Most participants documented mild or moderate injection-site reactions (ISRs), and mean ISR durations ranged from 1.0 to 14.5 days.
Conclusions:
The Brazil HARMONY study provides further support that a combination of HA injectables, biostimulators, and neuromodulators leads to significant improvements in participant satisfaction and psychological and social well-being on validated patient-reported outcome scales.
