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Navigating clozapine discontinuation in clinical practice: An updated framework
Grace Charter1, Nadezda Asceric1, Prashant Tibrewal1
1Cramond Clinic and MHSSU, The Queen Elizabeth Hospital (TQEH), Central Adelaide Health Network, Adelaide, South Australia, Australia.
Abstract:
Clozapine remains the most effective treatment for treatment-resistant schizophrenia (TRS), yet clinicians are frequently faced with situations where discontinuation must be considered due to adverse effects, patient preference, or lack of effectiveness. This article proposes an eight-step, clinically informed approach to guide the safe planning, implementation, and monitoring of clozapine discontinuation.
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