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Evaluating the potential of Cajanus cajan (L.) Millsp. Root to improve atopic dermatitis with different
Shu-Er Yang1, Xiang-Ming Cai2, Yu-Wen Chu3
1Department of Beauty Science and Master Program of Beauty Science and Technology, Chienkuo Technology University, Changhua, Taiwan.
Abstract:
Atopic dermatitis (AD) is a chronic inflammatory disease characterized by recurrent bacterial infections that cause pruritus, erythema, xerosis and thickening. Cajanus cajan root extract prepared with 95% ethanol (EECR95) has been shown to possess antioxidant, anti-inflammatory, and antibacterial properties in previous studies. This study aimed to evaluate EECR95's ability to improve AD by inhibiting methicillin-resistant Staphylococcus aureus (MRSA) growth and reducing inflammation. This study found EECR95 effectively inhibits MRSA growth (IC50 = 103.74 μg/mL) and reduces pro-inflammatory cytokine production in an MRSA-keratinocyte-macrophage model. LC/MS/MS analysis revealed the presence of active compounds-flavonoids, isoflavones, and flavonoid glycosides, highlighting EECR95's potential in improving atopic dermatitis in vitro.
