Related Experiment Video
Updated: Sep 27, 2026

Visualizing and Tracking Endogenous mRNAs in Live Drosophila melanogaster Egg Chambers
Published on: June 4, 2019
The discovery of maternal messenger RNA: fast-paced and transformative
1Department of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, MA 01605, U.S.
Abstract:
Some major discoveries come as the culmination of a long progression of incremental findings and evolving ideas. The discovery of maternal mRNA was different, its instancy noteworthy as a matter of epistemology. But it had a second impact, one that was far greater than the fast kinetics of the discovery per se. This was because it was the moment when embryology became molecular biology. This key event then soon aligned with genetics, deployed particularly in Drosophila and C. elegans, there proving this approach to be the emperor of all disciplines for the study of development. But the 1960's discovery of maternal mRNA, in the sea urchin, was the milestone in catalyzing this later heuristic vector.
Related Concept Videos
Experimental RNAi
Regulation of Expression Occurs at Multiple Steps
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
pre-mRNA Processing
Once about 20-40 ribonucleotides have been joined together by RNA polymerase, a group of enzymes adds a “cap” to the 5’ end of the growing transcript. In this process, a 5’ phosphate is replaced by modified guanosine that has a methyl group attached to it (7-Methyl guanosine). This 5’ cap helps the...
Nuclear Export of mRNA
Nuclear Export of mRNA
Regulated mRNA Transport

