Inherited Factor VII Deficiency Identified in a Patient with Acute Myeloid Leukemia: A Case Report

Factor VII (FVII) deficiency is a clinical condition occasionally encountered in the evaluation of coagulopathy. Although acquired FVII deficiency has been documented in association with acute myeloid leukemia (AML), the coexistence of AML and inherited FVII deficiency has not been previously reported. Here, we present a case of inherited factor VII deficiency concurrently identified in a patient with acute myeloid leukemia, in which targeted F7 gene sequencing identified compound heterozygosity for likely pathogenic variants. This case underscores that coagulopathy in patients with hematologic malignancies should not be reflexively attributed solely to acquired causes. Maintaining clinical suspicion for underlying inherited coagulation disorders is essential to prevent diagnostic oversights and to facilitate tailored management.