Related Experiment Video
Updated: Sep 27, 2026

Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers
Published on: July 28, 2022
Infant Colic and Simethicone
1Kaiser Permanente Sunnyside Medical Center, Clackamas, OR, USA sjgbell@gmail.com.
Abstract:
Infant colic or colic is a disorder of brain-gut interactions in infants less than 5 months of age. An infant with colic has bouts of prolonged crying without organic or environmental cause. Simethicone is an over-the-counter medication often prescribed in the outpatient setting as well as the NICU. This column provides an overview of colic, describes the Rome Criteria for colic in practice and research, discusses the gut-brain axis in neonatal development, reviews the pharmacology of simethicone, and reviews the evidence around the use of simethicone for colic.
Related Concept Videos
Drugs for Treatment of Constipation-Predominant IBS
Drugs Affecting GI Tract Motility: Other Laxatives
Osmotic or saline laxatives, like magnesium hydroxide or milk of...
Drugs for Treatment of Ulcerative Colitis in IBD
Drug Dosing: Infants and Children
Drugs for Treatment of Diarrhea-Predominant IBS
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Drugs Affecting GI Tract Motility: Bulk-Forming and Stimulant Laxatives
Bulk-forming laxatives, such as psyllium, methylcellulose, and polycarbophil, absorb water in the intestine, increasing stool bulk and promoting bowel movement. This makes...