Related Experiment Video
Updated: Sep 27, 2026
Label-Free Surface-Enhanced Raman Scattering Bioanalysis Based on Au@Carbon Dot Nanoprobes
Published on: June 9, 2023
Numerical Investigation of an Au-TiO2 Micro-Grating-Metastructure D-Shaped PCF-SPR Sensor for SARS-CoV-2-Related
Xing Wang1, Honggang Pan1, Dan Xia1
1Tianjin Key Laboratory of Film Electronic and Communication Devices, School of Integrated Circuit Science and Engineering, Tianjin University of Technology, Tianjin, China.
Abstract:
This study numerically investigates a D-shaped photonic crystal fiber (PCF) surface plasmon resonance (SPR) sensor integrated with an Au-TiO2 micro-grating metastructure for SARS-CoV-2-related biomolecular interaction analysis. The grating modulates phase matching between the core-guided and surface plasmon polariton modes, enhancing the refractive index (RI) response. The finite element method (FEM) was used to optimize the PCF air-hole diameters and Au-TiO2 grating parameters. The sensor shows a broad RI response range of 1.19-1.43, with a maximum local wavelength sensitivity (WS) of 18 500 nm/RIU, minimum full width at half maximum (FWHM) of 10 nm, and maximum figure of merit (FOM) of 240 RIU-1. For modeled spike RBD and anti-RBD monoclonal IgG binding, maximum WS values of 5000 and 4782 nm/RIU were obtained. These results support compact fiber-integrated SPR platforms for label-free monitoring of SARS-CoV-2-related RI variations, while specificity and reliability require experimental validation.
