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Updated: Sep 27, 2026

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer
Published on: April 13, 2015
Beyond End Protection: Shelterin, POT1 Dysfunction, and Telomere Replication Stress in Cancer
Tadahiko Matsumoto1, Akifumi Takaori-Kondo1
1Department of Hematology, Graduate School of Medicine, Kyoto University, Kyoto 606-8303, Japan.
Abstract:
Telomeres (chromosome-end nucleoprotein complexes) are prone to replication fork stalling because of their G-rich repetitive sequences, G-quadruplexes, t-loops, oxidative lesions, and telomeric R-loops generated when telomeric repeat-containing RNA (TERRA) hybridizes with telomeric DNA. In this review, we will summarize how telomeres are replicated and maintained and the mechanisms by which replication stress occurs at telomeres. Subsequently, we will review the role of POT1 mutations in cancer development and pathology and discuss therapeutic strategies targeting telomere biology in cancer.
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