TriAIF-RWKV: A Physiology-Guided Spatiotemporal Framework for Robust Arterial Input Function Selection in CT...

Accurate delineation of infarct core and ischemic penumbra in acute ischemic stroke primarily relies on computed tomography perfusion (CTP), where the arterial input function (AIF) is essential for reliable perfusion quantification. However, reliable and fast AIF selection remains challenging in clinical practice due to noise, vascular heterogeneity, and inter-patient variability in bolus dynamics. In this study, we propose TriAIF-RWKV, a three-stage framework for robust and automated AIF extraction. Specifically, ACSANet is first employed for spatial vascular localization using axial and channel-aware attention mechanisms, thereby narrowing the candidate arterial region and reducing the AIF search space. Then, a Dilated-RWKV network is introduced to model temporal intensity dynamics from a global sequence perspective, allowing robust identification of AIF-consistent patterns. Finally, a physiology-informed scoring strategy is used to select the optimal AIF by evaluating baseline stability, peak enhancement, and washout characteristics. Extensive experiments on CTP datasets were conducted from multiple perspectives, including AIF waveform fidelity, perfusion parameter estimation, and lesion-level analysis. The results demonstrate that the proposed method achieved high agreement with expert-selected AIFs, with a global waveform PCC of 0.973, peak correlation of 0.942, and TTP correlation of 0.973 with a mean error of 0.923 s. Furthermore, the proposed method provides more consistent downstream perfusion quantification, achieving higher consistency of CTP-derived parameters and improved lesion-to-normal tissue discrimination compared with existing approaches. These results highlight its potential for reliable clinical perfusion assessment.