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Updated: Sep 27, 2026

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death
Published on: December 27, 2016
Apoptosis Modulation by LL-37: From Mitochondrial Cell Death to Prosurvival Signaling
Olga Evgenevna Voronko1, Vitalia Sergeevna Novikova1, Olesya Olegovna Klychkova1
1Koltzov Institute of Developmental Biology of the Russian Academy of Sciences, Moscow 119334, Russia.
Abstract:
This review summarizes current knowledge on the role of human cathelicidin LL-37 in the regulation of apoptosis. LL-37 can modulate programmed cell death pathways, exerting either proapoptotic or antiapoptotic effects depending on various factors, such as cell type and peptide concentration. Data on LL-37 derivatives and their involvement in apoptosis are also discussed. Understanding the molecular mechanisms underlying LL-37 regulation of apoptosis is necessary to expand the therapeutic potential of this peptide in various pathological conditions, including cancer.
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