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Human Neuroendocrine Tumor Cell Lines as a Three-Dimensional Model for the Study of Human Neuroendocrine Tumor Therapy
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Human Neuroendocrine Tumor Cell Lines as a Three-Dimensional Model for the Study of Human Neuroendocrine Tumor Therapy

Published on: August 14, 2012

Neuroendocrine Tumors Have Outgrown the Orphan-Disease Framework: Building an Evidence Base for a Changing Field

Aman Chauhan1, Jaydira Del Rivero2

  • 1Division of Hematology and Oncology, University of California San Francisco, San Francisco, CA 94143, USA.

Cancers
|September 26, 2026
PubMed

Abstract:

For decades, one word shaped the story of neuroendocrine cancer: Rare [...].

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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

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