Insights on the Generation of Polymeric Drug Carriers via Supercritical Fluid-Assisted Technologies

Polymeric drug carriers have emerged as versatile platforms for improving therapeutic efficacy, drug stability and controlled and sustained release of active pharmaceutical ingredients. Conventional manufacturing techniques often rely on high processing temperatures, utilization of organic solvents and consequent purification procedures that may compromise morphology, encapsulation efficiency and carrier biocompatibility. Supercritical fluid technologies overcome the limitations of conventional methods and emerge as environmentally friendly, sustainable and flexible alternatives to produce advanced polymeric drug carriers. This review provides insights into the most widespread supercritical fluid technologies, encompassing the most recent advancements (2022-2026) made in the field of porous materials, micro- and nanoparticles and microcapsules. Emphasis was placed on carrier characteristics, features and applicative translation; this review aims at evidencing advantages, current limitations and future perspectives of supercritical fluid technologies, aiming at encouraging technological and industrial advancement of next-generation advanced polymeric drug carriers.