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Related Experiment Videos

Cutaneous and ocular reactions to practolol.

R H Felix, F A Ive, M G Dahl

    British Medical Journal
    |November 9, 1974
    PubMed
    Summary

    Practolol can cause various drug-induced rashes, including eczema-like and lupus-like eruptions. Some patients also experienced persistent ocular damage, highlighting potential severe side effects.

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    Area of Science:

    • Dermatology
    • Ophthalmology
    • Clinical Pharmacology

    Background:

    • Drug-induced rashes are a common adverse reaction to various medications.
    • Practolol, a beta-blocker, has been associated with cutaneous adverse events.

    Purpose of the Study:

    • To describe the clinical spectrum of drug-induced rashes caused by practolol.
    • To identify characteristic dermatological and ophthalmological manifestations.

    Main Methods:

    • Retrospective case series analysis.
    • Review of clinical presentations and outcomes in 21 patients over two years.

    Main Results:

    • Twenty-one patients presented with practolol-induced rashes.
    • Rash morphology varied, mimicking eczema, lupus erythematosus, lichen planus, and a psoriasiform eruption.
    • Three patients developed persistent ocular damage.

    Conclusions:

    • Practolol can induce a diverse range of skin eruptions.
    • Ocular complications are a potential concern in patients with practolol-induced dermatoses.

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