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Updated: Sep 28, 2026

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
Published on: November 11, 2016
From timekeeping to divisions-Molecular links between circadian rhythms and cell cycle
Sevde Goker1, Junghyun Lee2, Attila Csikász-Nagy3
1Department of Pharmacology, Physiology, and Neurobiology, University of Cincinnati College of Medicine, Ohio, USA.
Abstract:
Circadian rhythms and the cell cycle are two fundamental biological oscillators. They are linked through molecular mechanisms creating coupled oscillators where the outcomes of this coupling depend on numerous factors, such as the directionality of coupling (i.e., unidirectional vs. bidirectional), periods of the two oscillators, and the number and strength of connections. In this review, we provide a general overview of the links between circadian rhythms and the cell cycle and discuss potential implications of this connection in stem cell proliferation and differentiation of mammalian cells.
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