The Effects of Cyproheptadine on Severe COVID-19 From the I-SPY COVID Adaptive Platform Trial

Sara C Auld¹, Fady A Youssef¹, Timothy E Albertson¹+26

• ¹Division of Pulmonary, Allergy, Critical Care and Sleep Medicine (S. C. A.), Department of Medicine, Emory University, Atlanta, GA; the Pulmonary Division (F. A. Y.), Department of Internal Medicine, Long Beach Memorial Medical Centre, Long Beach; the Division of Pulmonary, Critical Care and Sleep Medicine (T. A.), Department of Medicine, University of California, Davis, Sacramento; the Division of Pulmonary Diseases and Critical Care Medicine (R. A. L.), Department of Medicine, University of California, Irvine, Irvine; the Hoag Memorial Hospital Presbyterian Center for Research and Education (P. R.), Newport Beach; the Department of Pulmonary and Critical Care Medicine (K. K. W.), Kaiser Permanente Los Angeles Medical Center, Los Angeles; the Division of Pulmonary, Critical Care, Allergy and Sleep Medicine (C. S. C. and M. A. M.), Department of Medicine, the Divisions of Nephrology and Critical Care Medicine (K. D. L.), Department of Medicine, the Department of Surgery (L. J. E.), University of California, San Francisco, San Francisco, CA; the Centre for Acute Respiratory Failure (J. R. B.), Columbia University, New York; the Department of Pulmonary and Critical Care Medicine (C. Q.), University of Rochester, Rochester, NY; the Department of Critical Care (P. A. B.), Sanford Health, Sioux Falls, SD; the Department of Medicine (E. L. B.), University of Colorado, Denver, CO; the Department of Pulmonary and Critical Care (N. C.), Georgetown University Medical Centre, Washington, DC; the Department of Medicine (E. F.), Main Line Health, Wynnewood; the Department of Medicine (N. J. M.), University of Pennsylvania Perelman School of Medicine, Philadelphia, PA; the Department of Pulmonary, Allergy, and Critical Care Medicine (S. G. and D. W. R.), University of Alabama at Birmingham, Birmingham, AL; the Department of Pulmonary Critical Care, Allergy and Immunologic Disease (K. W. G.), the Department of Internal Medicine (D. C. F.), Wake Forest University, Winston-Salem, NC; the Department of Cardiovascular and Thoracic Surgery (J. H.), Heart and Vascular Institute, West Virginia University, Morgantown, WV; the Division of Pulmonary and Critical Care Medicine (R. H.), Department of Medicine, University of Michigan, Ann Arbor; the Department of Pulmonary and Critical Care (M. M. H. S. K.), Spectrum Health, Grand Rapids, MI; the Section of Pulmonary, Critical Care, and Sleep Medicine (J. L. K.), Department of Medicine, Yale University, New Haven, CT; the Department of Critical Care Medicine (T. O.), Logan Health Research Institute, Kalispell, MT; the Department of Critical Care Medicine (S. S.), Mercy Hospital, Springfield, MO; the Pulmonary and Critical Care Division (R. G. W.), Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL; and the Department of Medical Epidemiology and Biostatistics (M. E.), Karolinska Institutet, Stockholm, Sweden.