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Updated: Sep 28, 2026

Genetic Mapping of Thermotolerance Differences Between Species of Saccharomyces Yeast via Genome-Wide Reciprocal Hemizygosity Analysis
Published on: August 12, 2019
Cross-species incompatibilities offer new insights into the functional consequences of satellite DNA evolution
Amber M Ridgway1,2, Piero Lamelza1, Michael A Lampson3
1Department of Biology, University of Pennsylvania, Philadelphia, PA, USA.
Abstract:
Tandemly repeated, non-coding satellite DNAs are among the most rapidly evolving genetic elements in eukaryotic genomes, changing in identity, copy number, and genomic distribution. A growing list of empirical studies suggests that this rapid evolution has profound consequences on core biological processes. Here, we review recent studies that investigate the satellite DNA-mediated biology revealed by generating either inter-species hybrids or genotypes expressing divergent, satellite DNA-interacting proteins from a closely related species. The genetic incompatibilities that arise implicate chromosome segregation, DNA repair, the establishment of silent heterochromatin, and the spatial organization of chromosomes as essential processes vulnerable to the rapid evolution of satellite DNA. We discuss emergent themes from this relatively young body of literature and future challenges for the field.
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