Association between CTLA4 +49A/G Polymorphism and Childhood Asthma Susceptibility: A Meta-analysis

To investigate the association between single nucleotide polymorphism (SNP) of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) +49A/G locus and the risk of asthma in children by meta-analysis. Six databases were searched for records on the association between CTLA-4 +49A/G locus polymorphism and pediatric asthma. The retrieval time was from the establishment of each database to July 2024. Stata 15.0 software was applied, with the pooled OR and 95% CI calculated. Five genetic models (G/A, GA+AA/AA, G/GA+AA, GG/AA, and GA/AA) were analyzed. Nine studies were included, covering 2133 Cases and 1572 controls. The combined results exhibited that the differences were all statistically significant under the allelic (OR, 0.53; 95% CI, 0.35-0.79), dominant (OR, 0.41; 95% CI, 0.24-0.71), recessive(OR, 0.60; 95% CI, 0.41-0.89), homozygous (OR, 0.38; 95% CI, 0.22-0.68) and heterozygous (OR, 0.52; 95% CI, 0.33-0.80) models. The meta-analysis indicates that CTLA-4 +49A/G SNP is related to susceptibility to pediatric asthma, and allele G and genotype GG+GA, GG, and GA correlated with a decreased risk of asthma.