Related Experiment Videos
Type 1 Diabetes is Associated With Increased Therapeutic Burden in Hidradenitis Suppurativa: A Multicenter
Irene Rivera-Ruiz1,2,3, Alberto Soto-Moreno4,5, Miguel Mansilla-Polo6,7
1Dermatology Department, Hospital Universitario Reina Sofía, Córdoba, Spain.
Background:
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease associated with multiple systemic comorbidities. Although its association with type 2 diabetes is well established, the clinical impact of coexisting type 1 diabetes (T1D) remains poorly defined.
Objectives:
To compare the clinical characteristics, disease burden, and therapeutic requirements of patients with HS and T1D with matched HS controls.
Methods:
We conducted a multicenter retrospective matched case-control study across 3 tertiary dermatology departments. Patients with HS and confirmed T1D were matched 1:3 by age, sex, and baseline Hurley stage. Clinical and therapeutic outcomes were assessed over a standardized 48 week follow-up.
Results:
Twelve patients with HS and T1D and 33 matched controls were included. Baseline disease severity was comparable. During follow-up, patients with HS + T1D had higher mean International Hidradenitis Suppurativa Severity Score System scores (11.95 vs 6.24; P = .01), more draining tunnels (11.0 vs 3.97; P < .01), received more systemic treatments (4.10 vs 3.06; P = .03), and underwent more surgical procedures (1.67 vs 0.67; P < .01).
Conclusions:
Patients with HS and coexisting T1D may experience a greater inflammatory and therapeutic burden than matched controls. These findings support closer multidisciplinary management and warrant prospective studies to validate T1D as a potential modifier of HS severity.
Limitations:
Retrospective design and small sample size.
Related Concept Videos
Type I Diabetes I: Introduction
Type I Diabetes II: Pathophysiology
Diabetes Mellitus: Overview and Type I Subtype
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type I Diabetes III: Clinical Manifestations
Type II Diabetes I: Introduction
Diabetes Mellitus: Type 2 and Gestational