Inhibition of phenylalanine hydroxylase by p-chlorophenylalanine; dependence on cofactor structure

Hyperphenylalaninemia and 7-pterin excretion associated with mutations in 4a-hydroxy-tetrahydrobiopterin dehydratase/DCoH: analysis of enzyme activity in intestinal biopsies.

Molecular genetics and metabolism·2000

Mutations in the pterin-4alpha-carbinolamine dehydratase (PCBD) gene cause a benign form of hyperphenylalaninemia.

Human genetics·1998

Stereospecificity and catalytic function of histidine residues in 4a-hydroxy-tetrahydropterin dehydratase/DCoH.

Biochemistry·1998

Activity of the bifunctional protein 4a-hydroxy-tetrahydropterin dehydratase/DCoH during human fetal development: correlation with dihydropteridine reductase activity and tetrahydrobiopterin levels.

Biochemical and biophysical research communications·1995

Catalytic characterization of 4a-hydroxytetrahydropterin dehydratase.

Biochemistry·1995

Role of C6 chirality of tetrahydropterin cofactor in catalysis and regulation of tyrosine and phenylalanine hydroxylases.

Biochemistry·1991

A dynamic homodimer structure of the response regulator FixJ from Bradyrhizobium japonicum in its phosphorylated state in aqueous solution.

Biochemical and biophysical research communications·2026

Cipepofol inhibits the proliferation, migration and invasion of breast cancer cells by inducing ferroptosis.

Biochemical and biophysical research communications·2026

Melatonin-loaded nanoparticles reduce cisplatin-induced oxidative stress and lymphopenia: An experimental study in rats.

Biochemical and biophysical research communications·2026

CCL2/CCR2 axis suggests a role in bridging obesity-related adipose inflammation to Sertoli cell injury in asthenozoospermia: Integrated multi-omics, machine learning and in vitro validation.

Biochemical and biophysical research communications·2026

Effects and mechanisms of Stauntonia brachyanthera Hand.-Mazz against Alzheimer's disease through network pharmacology and experimental validation.

Biochemical and biophysical research communications·2026

SIRT6 restrains hyperactivated Nrf2 to enhance cisplatin response in lung cancer models.

Biochemical and biophysical research communications·2026

Calpeptin and protein kinase C inhibition suppress exosome-associated inflammatory signaling and epidermal dysregulation in a 3-dimensional psoriatic skin model.

The Journal of pharmacology and experimental therapeutics·2026

Green Extraction Approach for Phenolic-Rich Peppermint Extracts Using Ultrasound: Impact of Solvent and Time Variables.

TheScientificWorldJournal·2026

Combined dorsal and ventral rhizotomy in non-ambulatory individuals with mixed spastic bilateral cerebral palsy: A prospective registry analysis.

Developmental medicine and child neurology·2026

Interfacial electron transfer and hydroxyl radical pathways in sulfate-enhanced perfluorobutanoic acid degradation on boron-doped diamond.

Journal of hazardous materials·2026

Rapid functionalization of single-walled carbon nanotubes in polar solvents.

Science advances·2026

Water-Based Perovskite Solar Cells: Precursor Chemistry, Reaction-Diffusion Kinetics, Processing Strategies, and Device Performance.

Nanomaterials (Basel, Switzerland)·2026

Related Experiment Videos

Inhibition of phenylalanine hydroxylase by p-chlorophenylalanine; dependence on cofactor structure

Related Concept Videos

Hyperphenylalaninemia and 7-pterin excretion associated with mutations in 4a-hydroxy-tetrahydrobiopterin dehydratase/DCoH: analysis of enzyme activity in intestinal biopsies.

Mutations in the pterin-4alpha-carbinolamine dehydratase (PCBD) gene cause a benign form of hyperphenylalaninemia.

Stereospecificity and catalytic function of histidine residues in 4a-hydroxy-tetrahydropterin dehydratase/DCoH.

Activity of the bifunctional protein 4a-hydroxy-tetrahydropterin dehydratase/DCoH during human fetal development: correlation with dihydropteridine reductase activity and tetrahydrobiopterin levels.

Catalytic characterization of 4a-hydroxytetrahydropterin dehydratase.

Role of C6 chirality of tetrahydropterin cofactor in catalysis and regulation of tyrosine and phenylalanine hydroxylases.

A dynamic homodimer structure of the response regulator FixJ from Bradyrhizobium japonicum in its phosphorylated state in aqueous solution.

Cipepofol inhibits the proliferation, migration and invasion of breast cancer cells by inducing ferroptosis.

Melatonin-loaded nanoparticles reduce cisplatin-induced oxidative stress and lymphopenia: An experimental study in rats.

CCL2/CCR2 axis suggests a role in bridging obesity-related adipose inflammation to Sertoli cell injury in asthenozoospermia: Integrated multi-omics, machine learning and in vitro validation.

Effects and mechanisms of Stauntonia brachyanthera Hand.-Mazz against Alzheimer's disease through network pharmacology and experimental validation.

SIRT6 restrains hyperactivated Nrf2 to enhance cisplatin response in lung cancer models.

Calpeptin and protein kinase C inhibition suppress exosome-associated inflammatory signaling and epidermal dysregulation in a 3-dimensional psoriatic skin model.

Green Extraction Approach for Phenolic-Rich Peppermint Extracts Using Ultrasound: Impact of Solvent and Time Variables.

Combined dorsal and ventral rhizotomy in non-ambulatory individuals with mixed spastic bilateral cerebral palsy: A prospective registry analysis.

Interfacial electron transfer and hydroxyl radical pathways in sulfate-enhanced perfluorobutanoic acid degradation on boron-doped diamond.

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Inhibition of phenylalanine hydroxylase by p-chlorophenylalanine; dependence on cofactor structure

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