Related Experiment Video
Updated: Sep 29, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
Blistering rash in an elderly patient
Francisco Martins1, Francisco Mano1, Felicidade Santiago1
1Dermatology Department, Coimbra's Local Health Unit, University Hospital, Coimbra, Celas, Portugal.
Abstract:
An 87-year-old man presented with a 6-week history of painful erosions on the left arm and both lower limbs requiring daily wound dressings. Examination showed multiple sharply demarcated, polygonal erosions with a striking geometric configuration. Although the morphology initially suggested traumatic or contact-related injury associated with wound care, direct immunofluorescence of perilesional skin demonstrated linear C3 deposition along the dermoepidermal junction, and serum anti-BP180 antibodies were positive, establishing the diagnosis of bullous pemphigoid. This case highlights that bullous pemphigoid may present predominantly with erosions rather than intact blisters, particularly in older patients undergoing repeated dressings, and emphasizes the importance of direct immunofluorescence when the clinical morphology is atypical.
Related Concept Videos
Rocky Mountain Spotted Fever
Endocarditis II: Clinical Features of Infective Endocarditis
Decreased Body Temperature
Changes in Skin Color: Clinical Perspectives
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Burn Injuries
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
Heart Failure III: Clinical Manifestations
