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Updated: Sep 29, 2026

An Engineered Split-TET2 Enzyme for Chemical-inducible DNA Hydroxymethylation and Epigenetic Remodeling
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A Chemogenetic System for Spatiotemporal Perturbation of Cellular Methylation Potential

Shusuke Ogihara1, Yuuta Fujikawa2, Ayaka Fujieda2

  • 1Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo113-0033, Japan.

ACS Chemical Biology
|September 28, 2026
PubMed

Keywords:
S-adenosylmethionine (SAM)chemogenetic approachmethylationmethyltransferase

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