Related Experiment Video
Updated: Sep 29, 2026
Comparison of Agreement and Accuracy using Binocular Wavefront Optometer with Autorefractor and Phoropter
Published on: September 16, 2025
Repeatability of an SD-OCT biometer and agreement with a validated biometer
Gianluca Cappuccini1, Kenneth J Hoffer, Arianna Grendele
1From the Studio Oculistico d'Azeglio, Bologna, Italy (Cappuccini, Grendele, Coutinho); St. Mary's Eye Center, Santa Monica, California (Hoffer); Stein Eye Institute, University of California, Los Angeles, California (Hoffer); Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy (Coutinho); I.R.C.C.S. Bietti Foundation, Rome, Italy (Schiano-Lomoriello, Savini); Unicamillus-Saint Camillus International University of Health Sciences, Rome, Italy (Schiano-Lomoriello).
Purpose:
To evaluate the repeatability of biometric measurements obtained with the MS-39 AL and to assess their agreement with those provided by the IOLMaster 700.
Setting:
IRCCS Bietti Foundation, Rome, Italy.
Design:
Prospective evaluation of diagnostic test.
Methods:
Patients were classified in Group A (with cataract) and Group B (with clear lens). For repeatability analysis, 3 measurements were obtained with the MS-39 AL. Agreement was analyzed by comparing the first MS-39 AL measurement with the corresponding measurement by the IOLMaster 700.
Results:
111 eyes were enrolled. Group A included 53 eyes (mean age: 69.4 ± 7.3 years) and Group B 58 eyes (mean age 35.5 ± 9.1 years). In both groups, the MS-39 AL demonstrated high repeatability for all biometric parameters, as the coefficient of variation ranged from 0.04% for axial length (AL) to 2.10% for lens thickness, except in the case of corneal astigmatism. Agreement between biometers was high for most parameters, with narrow 95% limits of agreement. Significant differences were observed for anterior chamber depth (MS-39 AL = 3.52 ± 0.44 mm, IOLMaster 700 = 3.42 ± 0.45 mm, P < .0001), corneal diameter (MS-39 AL = 11.90 ± 0.46 mm, IOLMaster 700 = 12.19 ± 0.49 mm, P < .0001), central corneal thickness (MS-39 AL = 531.75 ± 31.20 μm, IOLMaster 700 = 534.80 ± 32.79 μm, P < .001), and lens thickness (MS-39 AL = 4.18 ± 0.55 mm, IOLMaster 700 = 4.13 ± 0.52 mm, P = .002).
Conclusions:
The MS-39 AL provides highly repeatable biometric measurements and shows good agreement with the IOLMaster 700 for most parameters in both cataractous and clear-lens eyes.
