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Published on: August 19, 2015
MFG-E8 glycoprotein in inflammatory tissue regeneration: molecular mechanisms, therapeutic potential and advanced
Yuanyang Wang1, Tong Jin1, Ziwen Meng1
1School of Food and Biological Engineering, Engineering Research Center of Bio-process of Ministry of Education, Anhui Province Key Laboratory of Agricultural Products Modern Processing, Hefei University of Technology, Hefei, Anhui, PR China.
Abstract:
Milk fat globule epidermal growth factor 8 (MFG-E8) is a multifunctional glycoprotein that coordinates efferocytosis, inflammatory resolution, angiogenesis, and matrix remodeling during tissue repair. In ischemic and inflammatory microenvironments, endogenous MFG-E8 is functionally deficient due to proteolytic cleavage and oxidative inactivation, while free recombinant protein suffers from rapid clearance and poor targeting. Polymeric biomaterials, including nanoparticles, hydrogels, and extracellular vesicle carriers, offer protection, sustained release, and targeted delivery. This review systematically compares silk fibroin, PLGA, collagen, and chitosan-based platforms for MFG-E8 delivery, critically discusses translational bottlenecks (protein-polymer compatibility, manufacturing reproducibility, and safety), and proposes AI-driven co-engineering, closed-loop responsive systems, and biomarker-stratified strategies to accelerate clinical translation.
