The wu wei of brain metastases: When the gift of a pause is also a vulnerability
Anna Adam-Artigues1, Deisy Segura-Villalobos1, Julio A Aguirre-Ghiso2
1Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY, USA; Cancer Dormancy Institute, Montefiore Einstein Comprehensive Cancer Centre, Albert Einstein College of Medicine, Bronx, NY, USA; Gruss-Lipper Biophotonics Centre, Albert Einstein College of Medicine, Bronx, NY, USA; Ruth L. and David S. Gottesman Institute for Stem Cell Research and Regenerative Medicine, Albert Einstein College of Medicine, Bronx, NY, USA.
Abstract:
In this issue of Cancer Cell, García-Gómez et al. show that brain-seeding cancer cells exploit an MXD4-dependent proliferative pause that enables survival under stress before metastatic outgrowth. By restraining MYC and activating protective stress responses, this pause becomes an Achilles' heel, potentially targetable to eradicate micrometastases before clinical relapse.
Related Concept Videos
Coping Strategies: Problem Focused
For example, consider a student who struggles to understand their...
Coping Strategies: Emotion Focused
Post-traumatic Stress Disorder
Symptoms and Behavioral Manifestations
A spectrum of distressing symptoms characterizes PTSD. Recurrent flashbacks, where individuals involuntarily relive traumatic events, are a...

