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Updated: Sep 30, 2026

Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections
Published on: July 31, 2017
Lipid-autophagy crosstalk in glioblastoma: A context-dependent stress-adaptation interface under temozolomide
Mehdi Eshraghi1, Ivan Iurchenko2, Amir Barzegar Behrooz3
1Department of Human Anatomy and Cell Science, University of Manitoba, Max Rady College of Medicine, Winnipeg, Manitoba, Canada.
Abstract:
Glioblastoma (GB) is characterized by aggressive progression and frequent recurrence despite temozolomide (TMZ)-based therapy. Although resistance is commonly linked to DNA repair mechanisms, these pathways do not fully explain tumor persistence under therapeutic stress. Accumulating evidence suggests that metabolic reprogramming, particularly crosstalk between lipid metabolism and autophagy, may contribute to GB adaptation under TMZ-induced stress. We discuss how this lipid-autophagy interface may enable tumor cells to reconfigure energy production, maintain redox balance, and remodel membranes in response to therapy. Although the available evidence remains predominantly preclinical, convergent findings from lipidomic analyses and functional perturbation studies support lipid-autophagy crosstalk as an emerging contributor to TMZ resistance. This review presents this interaction as a testable conceptual framework for understanding metabolic adaptation to TMZ and discusses its potential therapeutic relevance.
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