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Updated: Sep 30, 2026

Fully Endoscopic Mitral Valve Repair with Percutaneous Cannulation of Groin Vessels
Published on: May 26, 2023
LATE ONSET PROSTHETIC VALVE ENDOCARDITIS: INSIGHTS INTO A PROSPECTIVE COHORT AND RISK FACTORS ASSOCIATED WITH
Guilherme S Pompeo1, Rinaldo Focaccia Siciliano2, Giovanna Ianini Ferraiuoli Barbosa3
1Instituto Nacional de Cardiologia, Rio de Janeiro 22240-006, Rio de Janeiro, Brazil; Hospital Pró Cardíaco, Rio de Janeiro 22280-003, Rio de Janeiro, Brazil.
Objectives:
To evaluate episodes of late prosthetic valve infective endocarditis (LPVIE) and mortality associated risk factors.
Methods:
We conducted an observational study of LPVIE cases recorded between 2006 and 2023 at two Brazilian cardiac surgery centres. Adults with a definite diagnosis of LPVIE according to the modified Duke criteria were included.
Results:
A total of 394 episodes were analyzed; 63.2% affected males. The mean age was 54.8 ± 17.39 years. Fever occurred in 77.9%, embolization in 20.6%, vegetations in 49.1% and paravalvular abscesses (PA) in 20.6% of patients. Blood cultures were negative in 21.1%. Surgery was indicated in 68.5% and performed in 81.9%. In-hospital mortality was 31%. Risk factors for mortality were acute renal failure, OR 32.80 (95% CI 13.38-80.38; p < 0.0001); PA, OR 9.37 (CI 3.23-27.15; p < 0.0001); failure to undergo surgery when indicated, OR 6.58 (CI 1.88-23.06; p = 0.003); acute heart failure, OR 4.65 (CI 1.95-11.09; p = 0.0005); dehiscence, OR 4.05 (95% CI 1.15-14.21; p = 0.029); age ≥ 60 years, OR 1.05 (95% CI 1.02-1.09; p = 0.0004).
Conclusion:
LPVIE was associated with high mortality and complications. Early identification of structural complications and timely surgical evaluation may improve prognosis.
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