Related Experiment Video
Updated: Sep 30, 2026

Isolation of Macrophage Subsets and Stromal Cells from Human and Mouse Myocardial Specimens
Published on: December 17, 2019
Evolution of macrophage function in sepsis-induced cardiomyopathy: Cellular networks from immune imbalance to
Wenye Xu1, Xianwen Wang1, Jinwei Dai1
1Department of Critical Care Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China; National Clinical Research Center for Geriatric Diseases, Xiangya Hospital, Central South University, Changsha, 410008, China; Critical Care and Neurocritical Sciences Study Group (CCNCSG), Xiangya Hospital, Central South University, Changsha, 410008, China.
Abstract:
Sepsis-induced cardiomyopathy (SICM) is an acute, often reversible myocardial depression driven by the host response to infection. Cardiac macrophages are central signaling hubs that integrate systemic danger signals and orchestrate myocardial dysfunction. We introduce a "Macrophage Functional Continuum" model, conceptualizing macrophages as dynamic signal integrators undergoing three interconnected phases: sensing and initiation, intrinsic reprogramming and fate determination, and multicellular network execution. Conceptually, these phases represent functional modules that may overlap in time and vary across organs, rather than a rigid chronological sequence. Stage-matched strategies-including immunometabolic modulation, checkpoint control, nanomedicine, and macrophage-based therapies-may provide a more context-sensitive therapeutic framework than conventional anti-inflammatory approaches. This review aims to reframe macrophage biology in SICM and provide a roadmap for translational research.
Related Concept Videos
Myocarditis I: Introduction
Chronic Inflammation: Introduction
Inflammation
Acute Inflammation III: Local and Systemic Effects
Acute Inflammation II: Cellular Phase
Immune Surveillance by NK Cells and Phagocytes
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
