Related Experiment Video

Updated: Sep 30, 2026

Assessment of the Metabolic Profile of Primary Leukemia Cells

Published on: November 21, 2018

Role of essential and trace elements in chronic myeloid leukemia: associations with serum trace element profiles and

Ajay Kumar Yadav¹, Umesh Choudhary¹, Anupam Aich²

¹Department of Anatomy, Institute of Medical Science, Banaras Hindu University, Varanasi, India.

Frontiers in Aging

|September 29, 2026

Abstract

Background:

Chronic myeloid leukemia is a myeloproliferative malignancy characterized by the Philadelphia chromosome with uncontrolled expansion of myeloid cells. Trace elements are essential for cellular metabolism, DNA repair, antioxidant defence, and immune regulation, and their imbalance may influence leukemogenesis and contribute to oxidative stress, immune dysregulation, and hematological alterations. Profiling trace elements may improve understanding of CML-associated trace element alterations and identify candidate biomarkers for future validation.

Material And Methods:

A cross-sectional study at Banaras Hindu University, India, included 93 CML patients and 93 age and sex-matched healthy controls from an eastern Indian population. Serum chromium (Cr), copper (Cu), manganese (Mn), lead (Pb), cadmium (Cd), arsenic (As), iron (Fe), selenium (Se), and zinc (Zn) concentrations were measured by atomic absorption spectroscopy. Complete blood counts were performed, and data analysed using descriptive statistics, Mann-Whitney U test, Chi-square/Fisher's exact tests, and Spearman correlation analysis.

Results:

CML patients exhibited significantly elevated serum concentrations of Cu, Mn, Pb, Cd, and As compared with healthy controls, whereas Cr, Fe, Se, and Zn concentrations were significantly higher in healthy controls. Several trace elements showed statistically significant associations with hematological parameters, suggesting complex interactions between elemental imbalance and CML biology.

Conclusion:

This study strongly shows dysregulation of essential and toxic trace elements in CML. Imbalance of selenium (Se), zinc (Zn), iron (Fe), manganese (Mn), and copper (Cu) may contribute to oxidative stress, immune dysfunction, and leukemogenesis, and toxic metals may enhance genomic instability. Trace-element profiling, especially selenium-related biomarkers, may serve as candidate biomarkers associated with CML and warrant validation in larger prospective studies.

Keywords:

chronic myeloid leukemia copper iron selenium serum biomarkers trace element profiling zinc

More Related Videos

Identifying Bone Marrow Microenvironmental Populations in Myelodysplastic Syndrome and Acute Myeloid Leukemia

Identifying Bone Marrow Microenvironmental Populations in Myelodysplastic Syndrome and Acute Myeloid Leukemia

Published on: November 10, 2023

Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia

Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia

Published on: March 5, 2018

Related Concept Videos

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...

Essential Minerals for Bone Health

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...

Minerals

Minerals

Minerals are essential nutrients that the human body needs in small amounts to work properly. They play a vital role in many bodily functions, such as building strong bones and transmitting nerve impulses. Some minerals are needed for hormone production or to maintain a normal heartbeat. Major minerals include calcium, phosphorus, potassium, sulfur, sodium, chlorine, and magnesium, while trace minerals include iron, manganese, copper, iodine, zinc, cobalt, fluoride, and selenium.

Role of Hematopoietic Growth Factors

Role of Hematopoietic Growth Factors

Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...

Disorders of Leukocytes

Disorders of Leukocytes

Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...

Introduction to Electrolytes

Introduction to Electrolytes

In humans, electrolytes play a vital role in various physiological processes. Balancing electrolyte levels is essential for normal body functions; their imbalance can be life-threatening. The major electrolytes include sodium, potassium, chloride, calcium, phosphate, and bicarbonate. They are primarily involved in physiological processes, such as nerve signal transmission, membrane trafficking, muscle contraction, buffering body fluids, and balancing water levels in the body.
Role of Sodium
One...

Articles linked to this work by shared authors, journal, and citation graph.

An Anthropometric Study of the Facial Index Among Undergraduate Medical Students at the Institute of Medical Sciences, Banaras Hindu University, Uttar Pradesh.

Cureus·2026

Alginate Micro-fibers encapsulated with oregano essential oil with improved antibacterial efficacy.

RSC advances·2026

A new deep-sea squat lobster (Decapoda: Anomura) from a seamount of the Arabian Sea, India, with re-description of Gonionida comorina (Alcock & Anderson, 1899).

Zootaxa·2026

Status of Nuclear Medicine in Nepal: Current Infrastructure, Challenges, and Future Perspectives.

World journal of nuclear medicine·2026

Decoding Genetic Risk Factors in Recurrent Pregnancy Loss: An Integrative Chromosomal and Bioinformatics Approach.

Biochemical genetics·2026

Transport of Engineered Nanoparticles in Solid Tumors: Mechanistic Barriers and Emerging Delivery Strategies.

Bioconjugate chemistry·2026

See all related articles